Table 2 ER stress-associated candidate genes

Ribosome binding protein 1

Rrbp1

mainly located in the ER [30, 31], critical for ribosome binding and transportation and secretion [30, 32].

involved in the tumorigenesis, including, esophageal carcinoma, bladder cancer, prostate cancer, lung cancer [29, 30, 32, 33].

Cysteine-rich with EGF-like domains 2

Creld2

located in the ER, identified as a novel ERS inducible gene [34].

involved in the ER-stress-mediated kidney disease and aortic aneurysm in Marfan syndrome, osteogenic differentiation [35,36,37,38].

Protein disulphide isomerase-3

Pdia3

mainly located in the ER [39],belongs to the protein disulphide isomerase family and catalyses the reduction, oxidation and isomerization of the substrate disulfide bond [39, 40].

involved in the assembly of MHC, the blood platelet aggregation and thrombosis, the sperm-oocyte fusion [39,40,41,42].