Fig. 8

Differential gene expression profiles among mice with apoptotic luminal epithelia. A Principal component analysis of gene expression data from high-fat diet endometrial epithelia based on luminal CC3, > 10% or < 10%. B Volcano plot of expressed genes in epithelia of two groups. Significant differentially expressed genes (FDR < 0.05) among > 10% CC3 epithelia compared to < 10% CC3 epithelia are highlighted in red. Genes with FDR < 0.001 are denoted with gene symbols. C, D Enrichment analysis for GO biological processes for upregulated genes (n = 187) (C) or downregulated genes (n = 144) (D). E Principal component analysis of gene expression data from high-fat diet macrophages based on luminal CC3. F Volcano plot of expressed genes in macrophages of two groups. Significant differentially expressed genes (FDR < 0.05) are highlighted in red. Genes with FDR < 0.001 are denoted with gene symbols. G, H Enrichment analysis for GO biological processes for upregulated genes (n = 263) (G) or downregulated genes (n = 388) (H) among macrophages from > 10% CC3 and < 10% CC3 groups