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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Identification of a novel ESR1 mutation in a Chinese PCOS woman with estrogen insensitivity in IVF treatment

Fig. 2

Evolutionary conservation analysis and protein structural modelling of the ESR1 (p.A207T) mutatiom. A Representative sequencing electropherogram of the ESR1 (p.A207T) mutation. The arrow indicates the location of the mutation. B Evolutionary conservation analysis of the ESR1 (p.A207T) mutation. Sequence alignment with other species indicates that the affected Ala (A) 207 residue is highly conserved in all 18 vertebrate species. C Structural difference between wild type ESR1 (p.A207) and mutated ESR1 (p.T207) proteins. The protein structures of wild type and mutated ESR1 proteins were modelled based on the crystal model of the human ESR1 protein. D Location of ESR1 missense mutations found in clinical samples. The A207 residue (red text) shows the novel mutation identified in our study. AF1, activation function 1; DBD, DNA binding domain; AF2, activation function 2; LBD, ligand binding domain

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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