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Table 4 The DNA Methylation levels of selected candidate genes in patients with severely impaired sperm DNA.

From: Poor semen parameters are associated with abnormal methylation of imprinted genes in sperm DNA

Gene

CpG Sites

DMP

DMP(%)

Case Value

Control Value

P Value

IGF-2

105

16

15.2

0.009 ± 0.002

0.010 ± 0.004

0.029

KCNQ1

27

0

0

0.007 ± 0.002

0.007 ± 0.002

0.321

KCNQ1OT1

41

21

51.2

0.040 ± 0.036

0.055 ± 0.064

0.066

MEG3

35

22

62.9

0.027 ± 0.027

0.043 ± 0.066

0.026

MEST

96

33

34.4

0.030 ± 0.031

0.045 ± 0.064

0.043

PEG3

19

19

100

0.027 ± 0.029

0.045 ± 0.063

0.014

  1. Case:severely impaired sperm DNA group (DFI > 30%); Control:low DFI group(DFI ≤ 30%); Bold values was statistically significant (P < 0.05)
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