Exposure | Values mean ± SD / n (%) | Change in birthweight(g) β(95%CI) | P value |
---|---|---|---|
Maternal age (y) | 30.92 ± 3.95 | −1.20 (−6.12, 3.73) | 0.6338 |
Paternal age (y) | 32.46 ± 4.77 | −0.37 (−4.44, 3.70) | 0.8571 |
Maternal BMI (kg/m2) | 22.25 ± 3.12 | 15.97 (9.79, 22.15) | < 0.0001 |
Basal FSH | 7.66 ± 2.46 | −1.05 (− 8.95, 6.85) | 0.7948 |
AMH | 2.87 ± 2.24 | 5.09 (−3.57, 13.75) | 0.2495 |
Type of infertility | |||
Primary | 934 (50.60%) | Ref | |
Secondary | 912 (49.40%) | 30.32 (−8.50, 69.14) | 0.1260 |
Infertility duration (y) | 3.65 ± 2.69 | −6.65 (−13.85, 0.56) | 0.0708 |
Infertility cause | |||
Female | 1196 (64.79%) | Ref | |
Male | 362 (19.61%) | −27.00 (−77.04, 23.05) | 0.2906 |
Mixed | 175 (9.48%) | 25.37 (−42.16, 92.89) | 0.4616 |
Unexplained | 113 (6.12%) | −34.34 (− 116.45, 47.77) | 0.4125 |
Prior gonadotropin cycle | 1.22 ± 0.54 | −9.29 (−44.99, 26.41) | 0.6101 |
COS protocols | |||
GnRH-a long protocol | 1211 (65.60%) | Ref | |
Antagnist protocol | 635 (34.40%) | −52.70 (−94.43, −10.96) | 0.0134 |
Dosage of gonadotropins (IU) | 2277.14 ± 1114.47 | 0.02 (−0.00, 0.03) | 0.0764 |
Stimulation duration (days) | 11.57 ± 2.20 | 9.36 (0.55, 18.18) | 0.0375 |
E2 level on HCG day (100 pg/ml) | 29.96 ± 12.67 | −5.49 (−8.83, −1.23) | 0.023 |
Number of oocytes retrieved | 9.68 ± 3.81 | 2.63 (− 2.47, 7.72) | 0.3120 |
Fertilization method | |||
IVF | 1218 (65.98%) | Ref | |
ICSI | 535 (28.98%) | −29.85 (−73.09, 13.39) | 0.1762 |
IVF + ICSI | 93 (5.04%) | −92.14 (−182.74, − 1.54) | 0.0464 |
Stage embryo transferred | |||
D3 | 1542 (83.53%) | Ref | |
D5 | 304 (16.47%) | 13.04 (−39.32, 65.40) | 0.6255 |
Number of embryos transferred | |||
1 | 498 (26.98%) | Ref | |
2 | 1344 (72.81%) | 22.23 (−21.54, 66.00) | 0.3197 |
3 | 4 (0.22%) | 141.86 (− 276.99, 560.71) | 0.5069 |
Endometrial thickness (mm) | 9.97 ± 1.53 | 8.59 (−4.09, 21.27) | 0.1844 |
Endometrial type | |||
A | 28 (1.52%) | Ref | |
A-B | 104 (5.63%) | 54.59 (− 122.82, 232.01) | 0.5465 |
B | 564 (30.55%) | 91.85 (−69.49, 253.20) | 0.2646 |
B-C | 1023 (55.42%) | 106.98 (−52.65, 266.60) | 0.1892 |
C | 127 (6.88%) | 183.22 (9.24, 357.19) | 0.0391 |
Gender of newborn | |||
Male | 927 (50.22%) | Ref | |
Female | 919 (49.78%) | −109.08 (− 147.60, − 70.56) | < 0.0001 |