Characteristics | ≤2000 ng/ml | 2001–3000 ng/ml | 3001–4000 ng/ml | >4000 ng/ml | P value |
---|---|---|---|---|---|
(n = 462) | (n = 486) | (n = 453) | (n = 445) | ||
Baseline characteristics | |||||
Maternal age (y) | 32.05 ± 4.12 | 30.94 ± 3.90 | 30.45 ± 3.84 | 30.18 ± 3.67 | < 0.001 |
Paternal age (y) | 33.64 ± 5.01 | 32.53 ± 4.85 | 31.88 ± 4.52 | 31.78 ± 4.46 | < 0.001 |
Maternal BMI (kg/m2) | 22.64 ± 3.01 | 22.53 ± 3.34 | 21.97 ± 2.85 | 21.83 ± 3.18 | < 0.001 |
Basal FSH (IU/L) | 8.98 ± 3.19 | 7.53 ± 2.32 | 7.10 ± 1.75 | 6.99 ± 1.73 | < 0.001 |
AMH (ng/ml) | 1.62 ± 1.79 | 2.63 ± 2.00 | 3.52 ± 2.34 | 3.76 ± 2.17 | < 0.001 |
Type of infertility | 0.145 | ||||
Primary | 216 (46.75%) | 261 (53.70%) | 224 (49.45%) | 233 (52.36%) | |
Secondary | 246 (53.25%) | 225 (46.30%) | 229 (50.55%) | 212 (47.64%) | |
Infertility duration (y) | 3.89 ± 2.85 | 3.58 ± 2.63 | 3.54 ± 2.60 | 3.59 ± 2.68 | 0.166 |
Infertility cause | 0.377 | ||||
Female | 314 (67.97%) | 304 (62.55%) | 290 (64.02%) | 288 (64.72%) | |
Male | 80 (17.32%) | 105 (21.60%) | 88 (19.43%) | 89 (20.00%) | |
Mixed | 45 (9.74%) | 44 (9.05%) | 39 (8.61%) | 47 (10.56%) | |
Unexplained | 23 (4.98%) | 33 (6.79%) | 36 (7.95%) | 21 (4.72%) | |
Prior gonadotropin cycle | 1.42 ± 0.76 | 1.19 ± 0.45 | 1.13 ± 0.40 | 1.13 ± 0.44 | < 0.001 |
Ovarian stimulation parameters | |||||
COS protocols | < 0.001 | ||||
GnRH-a long protocol | 196 (42.42%) | 300 (61.73%) | 345 (76.16%) | 370 (83.15%) | |
Antagnist protocol | 266 (57.58%) | 186 (38.27%) | 108 (23.84%) | 75 (16.85%) | |
Dosage of gonadotropins (IU) | 2748.01 ± 1110.08 | 2407.71 ± 1118.06 | 2118.14 ± 1113.68 | 1807.56 ± 870.33 | < 0.001 |
Stimulation duration (days) | 10.82 ± 2.33 | 11.53 ± 2.03 | 12.05 ± 2.18 | 11.90 ± 2.06 | < 0.001 |
E2 level on HCG day (pg/ml) | 1413.19 ± 439.51 | 2493.55 ± 293.11 | 3477.02 ± 290.95 | 4697.74 ± 521.27 | < 0.001 |
Number of oocytes retrieved | 6.09 ± 3.00 | 9.48 ± 2.94 | 11.11 ± 3.06 | 12.18 ± 3.21 | < 0.001 |
Retrieved MII Oocytes | 5.30 ± 2.59 | 8.04 ± 2.64 | 9.49 ± 2.95 | 10.57 ± 3.20 | < 0.001 |
Fertilization method | 0.180 | ||||
IVF | 319 (69.05%) | 308 (63.37%) | 294 (64.90%) | 297 (66.74%) | |
ICSI | 128 (27.71%) | 145 (29.84%) | 132 (29.14%) | 130 (29.21%) | |
IVF + ICSI | 15 (3.25%) | 33 (6.79%) | 27 (5.96%) | 18 (4.04%) | |
Fertilization rate | 85.10 ± 17.35 | 83.29 ± 15.39 | 81.58 ± 16.48 | 82.39 ± 15.86 | 0.008 |
Number of available embryos | 3.07 ± 1.63 | 4.37 ± 2.20 | 4.96 ± 2.24 | 5.72 ± 2.51 | < 0.001 |
Stage embryo transferred | < 0.001 | ||||
D3 | 429 (92.86%) | 412 (84.77%) | 363 (80.13%) | 338 (75.96%) | |
D5 | 33 (7.14%) | 74 (15.23%) | 90 (19.87%) | 107 (24.04%) | |
Number of embryos transferred | 0.011 | ||||
1 | 120 (25.97%) | 108 (22.22%) | 131 (28.92%) | 139 (31.24%) | |
2 | 339 (73.38%) | 377 (77.57%) | 322 (71.08%) | 306 (68.76%) | |
3 | 3 (0.65%) | 1 (0.21%) | 0 (0.00%) | 0 (0.00%) | |
Endometrial thickness (mm) | 9.81 ± 1.51 | 10.07 ± 1.57 | 9.97 ± 1.56 | 10.03 ± 1.48 | 0.057 |
Endometrial type | 0.388 | ||||
A | 5 (1.08%) | 11 (2.26%) | 5 (1.10%) | 7 (1.57%) | |
A-B | 24 (5.19%) | 22 (4.53%) | 29 (6.40%) | 29 (6.52%) | |
B | 149 (32.25%) | 151 (31.07%) | 128 (28.26%) | 136 (30.56%) | |
B-C | 252 (54.55%) | 269 (55.35%) | 268 (59.16%) | 234 (52.58%) | |
C | 32 (6.93%) | 33 (6.79%) | 23 (5.08%) | 39 (8.76%) | |
Neonatal outcomes indicators | |||||
Gender of newborn | 1.000 | ||||
Male | 232 (50.22%) | 244 (50.21%) | 228 (50.33%) | 223 (50.11%) | |
Female | 230 (49.78%) | 242 (49.79%) | 225 (49.67%) | 222 (49.89%) | |
Newborn height | 50.37 ± 1.73 | 50.40 ± 1.67 | 50.37 ± 1.88 | 50.54 ± 1.67 | 0.388 |
GA (week) | 39.32 ± 0.99 | 39.38 ± 1.12 | 39.38 ± 1.14 | 39.38 ± 1.00 | 0.744 |
Birthweight (g) | 3440.94 ± 449.91 | 3438.92 ± 388.16 | 3366.19 ± 447.61 | 3322.45 ± 415.85 | 0.021 |
Z-score | 0.14 ± 1.14 | 0.13 ± 0.95 | − 0.05 ± 1.10 | −0.12 ± 0.97 | 0.004 |
Birthweight | 0.040 | ||||
Normal birthweight | 418 (90.48%) | 450 (92.59%) | 406 (89.62%) | 400 (89.89%) | |
Very low birth weight(<1500 g) | 0 (0.00%) | 0 (0.00%) | 0 (0.00%) | 5 (1.12%) | |
Low birthweight(<2500 g) | 9 (1.95%) | 1 (0.21%) | 10 (2.21%) | 15 (3.37%) | |
Fetal macrosomia(≥4000 g) | 35 (7.58%) | 35 (7.20%) | 37 (8.17%) | 25 (5.62%) | |
Small for gestational age | 31 (6.71%) | 26 (5.35%) | 38 (8.39%) | 42 (9.44%) | 0.020 |
Very small for gestational age | 12 (2.60%) | 3 (0.62%) | 9 (1.99%) | 10 (2.25%) | 0.114 |
Large for gestational age | 41 (8.87%) | 44 (9.05%) | 46 (10.15%) | 29 (6.52%) | 0.263 |
Very large for gestational age | 16 (3.46%) | 10 (2.06%) | 20 (4.42%) | 10 (2.25%) | 0.125 |
Mode of delivery | 0.028 | ||||
Vaginal | 140 (30.30%) | 182 (37.45%) | 161 (35.54%) | 175 (39.33%) | |
Caesarean section | 322 (69.70%) | 304 (62.55%) | 292 (64.46%) | 270 (60.67%) |