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Table 1 Comparison of in vitro growth of HA encapsulated follicles from fresh versus vitrified ovaries

From: New hyaluronan-based biomatrix for 3-D follicle culture yields functionally competent oocytes

 

Fresh

Fresh

Frozen

P-Value

FL-Isolated

FL-Cluster

FL-Cluster

 
 

130

154

69

 

Antrum formation

51%(66/130)

53% (81/154)

-

 

Ovulated complexes after hCG

71% (92/130)

66% (101/154)

93% (64/69)

0.0001

GVBD (MI formation)

30% (28/92)

28% (28/101)

52% (33/64)

0.004

Maturation to MII

59% (54/92)

55% (56/101)

34%( 22/64)

0.007

  1. This table contrasts outcomes between fresh and frozen ovaries. These data show that all outcome parameters for FL-Isolated and FL-Clusters from fresh ovaries were similar but differed significantly with results from frozen ovaries. The final maturation rate to MII was significantly lower with FL-Clusters from frozen ovaries versus fresh FL-Isolated or fresh FL-cluster