Fig. 7

RNA-seq analysis of gene expression in 4-month old WT and DKO testes. a Venn diagram of differential gene expression shows that 263 genes are significantly upregulated in DKO in comparison to WT, with only 17 genes overlapping the P2KO profile. Significance was set as FDR < 0.05 and p-adj < 0.05. Gene lists are provided in Supplementals 4 and 5. b-c Gene ontology analysis with DAVID 6.8 divides these upregulated genes into b Biological Processes with reproductive pathways heavily represented and c Molecular Functions almost entirely represented by genes involved in nucleic acid regulation