Fig. 6

Padi2/Padi4 DKO male mice have disrupted testicular development. In comparisons of 90-day old DKO to WT mice, DKO have a significantly smaller testes (n=5, one-tailed t-test, *P = 0.002) and b significantly lower gonadosomatic index (testes weight as % of body weight; n=5, one-tailed t-test, **P = 0.037). c Hematoxylin and Eosin stained sections of WT testis showing normal spermatogenic cell structures. d-f Hematoxylin and Eosin stained sections of DKO testis. Black arrows indicate: d apoptotic spermatogonia, e apoptotic spermatocytes and f atypical residual bodies (scale bars = 50 𝜇m)