Fig. 4

Pubertal onset is delayed in Padi2/Padi4 DKO male mice. a Preputial separation occurred later in DKO males than WT and SKO strains, with b the mean age of PS significantly higher (n=49, 36, 38, 46; ANOVA, P < 0.0001). c Smaller body size at weaning does not appear to be a factor, as DKO mice are significantly larger when they reach PS than all other strains (ANOVA, P = 0.0002), and d there is no significant difference in body weight between strains at day 27, the mean day of PS for WT and SKO mice (ANOVA, P = 0.5)