Variable | Follitropin delta (n = 378) | Follitropin alfa (n = 381) | P-value |
---|---|---|---|
Gonadotropin use | |||
Duration of stimulation (days) | 9.2 ± 1.8 | 8.8 ± 1.5 | 0.025a |
Total dose (μg) | 76.7 ± 23.8 | 110.4 ± 31.2 | < 0.001a |
Average daily dose (μg/day) | 8.5 ± 2.3 | 12.4 ± 1.6 | < 0.001a |
Number of follicles at end of stimulation | |||
Total number of follicles | 12.8 ± 5.6 | 14.2 ± 6.5 | 0.005a |
Follicles ≥ 12 mm | 10.7 ± 5.0 | 12.0 ± 5.7 | 0.006a |
Follicles ≥ 17 mm | 4.3 ± 1.8 | 4.5 ± 2.0 | 0.359a |
Endocrine profile at end of stimulation | |||
FSH (IU/l) | 11.5 | 12.4 | < 0.001b |
LH (IU/l) | 1.7 | 1.9 | 0.011b |
Estradiol (pmol/l) | 7001 | 9130 | < 0.001b |
Progesterone (nmol/l) | 2.3 | 3.1 | < 0.001b |
Progesterone > 3.18 nmol/L | 121 (32.4%) | 190 (50.7%) | < 0.001c |
Inhibin A (ng/l) | 361.2 | 449.3 | < 0.001b |
Inhibin B (ng/l) | 1022.6 | 1134.7 | 0.002b |
Cancellations | |||
Cycle cancellation | 12 (3.2%) | 5 (1.3%) | 0.085c |
Cycle or transfer cancellation | 56 (14.8%) | 71 (18.6%) | 0.126c |
Oocytes and embryos | |||
Women with at least one oocyte retrieved | 364 (96.3%) | 375 (98.4%) | 0.068c |
Oocytes retrieved (n) | 10.3 ± 6.2 | 12.5 ± 7.5 | < 0.001a |
Fertilized oocytes (n) | 6.4 ± 4.2 | 7.7 ± 5.0 | < 0.001a |
Fertilization rated (%) | 63.2 ± 22.8 | 62.8 ± 21.5 | 0.365a |
Day 3 embryos (n) | 7.3 ± 4.7 | 8.8 ± 5.5 | < 0.001a |
Day 3 good-quality embryos (n) | 4.4 ± 3.8 | 5.3 ± 4.2 | 0.002a |
OHSS | |||
Any OHSS | 34 (9.0%) | 36 (9.4%) | 0.764c |
Early OHSS (any grade)e | 18 (4.8%) | 28 (7.3%) | 0.115c |
Late OHSS (any grade)f | 16 (4.2%) | 8 (2.1%) | 0.098c |
Preventive interventionsg for early OHSS | 6 (1.6%) | 16 (4.2%) | 0.025c |
Early OHSS and/or preventive interventions | 23 (6.1%) | 42 (11.0%) | 0.011c |