Table 1 Demographics and baseline characteristics of study population
Characteristics | Follitropin delta group (n = 378) | Follitropin alfa group (n = 381) |
|---|---|---|
Age (years) | 30.6 ± 3.6 | 30.8 ± 3.6 |
< 35 | 312 (82.5%) | 313 (82.2%) |
35–37 | 55 (14.6%) | 52 (13.6%) |
38–40 | 11 (2.9%) | 16 (4.2%) |
Body weight (kg) | 56.0 ± 8.0 | 56.5 ± 7.9 |
BMI (kg/m2) | 21.8 ± 2.7 | 22.0 ± 2.8 |
Infertility history | ||
Duration of infertility (months) | 42.2 ± 24.4 | 45.3 ± 28.2 |
Primary infertility | 244 (64.6%) | 223 (58.5%) |
Reason for infertility | ||
Unexplained infertility | 74 (19.6%) | 66 (17.3%) |
Tubal infertility | 197 (52.1%) | 204 (53.5%) |
Male factor | 98 (25.9%) | 106 (27.8%) |
Endometriosis stage I/II | 5 (1.3%) | 2 (0.5%) |
Other | 4 (1.1%) | 3 (0.8%) |
Endometrial thickness (mm) | 6.1 ± 2.2 | 6.1 ± 2.1 |
Ovarian volume (cm3) | 5.0 ± 2.2 | 4.9 ± 2.5 |
AFCa | 15.4 ± 6.2 | 15.0 ± 5.6 |
Endocrine profileb | ||
AMH (pmol/l)c | 25.9 ± 13.6 | 26.1 ± 16.1 |
AMH < 15 pmol/l | 77 (20.4%) | 86 (22.6%) |
AMH ≥ 15 pmol/l | 301 (79.6%) | 295 (77.4%) |
FSH (IU/l) | 7.3 (6.1–8.5) | 7.2 (6.2–8.2) |
LH (IU/l) | 3.7 (2.9–4.8) | 3.7 (2.8–4.9) |
Estradiol (pmol/l) | 140 (113.1–164.5) | 142.2 (112.1–176.4) |
Progesterone (nmol/L) | 0.8 (0.8–2.1) | 0.8 (0.8–2.1) |
Inhibin A (ng/L) | 5.0 (4.0–6.5) | 5.3 (4.0–6.5) |
Inhibin B (ng/L) | 81.0 (62.0–101.5) | 82.0 (67.0–101.0) |
Algorithmic dose (µg/day)d | 8.5 ± 2.3 | 8.8 ± 2.4 |