The impact of different endometrial preparation protocols on obstetric and neonatal complications in frozen-thawed embryo transfer: a retrospective cohort study of 3,458 singleton deliveries

Table 2 Obstetric and neonatal complications for singleton births based on endometrial preparation protocols

	Programmed cycles	Natural cycles	Minimal ovarian stimulation cycles	P value
	n = 2,029	n = 959	n = 470	P value
Obstetric complications
HDP^a	115 (5.7)	27 (2.8)	25 (5.3)	0.003^b
GDM	28 (1.4)	11 (1.1)	9 (1.9)	NS^b
ICP	16 (0.8)	7 (0.7)	1 (0.2)	NS^c
Placenta previa	49 (2.4)	15 (1.6)	10 (2.1)	NS^b
PROM	63 (3.1)	34 (3.5)	14 (3.0)	NS^b
Preterm delivery^ad	159 (7.8)	50 (5.2)	40 (8.5)	0.017^b
Postpartum haemorrhage	30 (1.5)	6 (0.6)	2 (0.4)	NS^c
Neonatal complications
LGA^ae	387 (19.1)	144 (15.0)	62 (13.2)	0.001^b
SGA^e	86 (4.2)	54 (5.6)	35 (7.4)	0.011^b
Macrosomia	45 (2.2)	15 (1.6)	8 (1.7)	NS^b

Values are presented as n (%)
HDP hypertensive disorders of pregnancy, GDM gestational diabetes mellitus, ICP intrahepatic cholestasis of pregnancy, PROM preterm rupture of membrane, LGA large for gestational age, SGA small for gestational age
^aStatistically significant differences between programmed cycles and natural cycles
^bPearson chi-square test
^cFisher’s exact test
^dStatistically significant differences between natural cycles and minimal ovarian stimulation cycles
^eStatistically significant differences between programmed cycles and minimal ovarian stimulation cycles

ISSN: 1477-7827