Fig. 4

Differentially expressed metabolites in PTB mice. A Heatmap of 50 differential metabolites determined by LC–MS. Hierarchical clustering analysis was used to assess significantly regulated metabolites between CTL and PTB groups. Increased and decreased metabolites are depicted by red and blue, respectively. B The volcano map of all metabolites expressed in CTL and PTB groups. C The differential metabolites could be roughly categorized into several classes. D Enriched metabolic pathway clustering analysis. E IPA of metabolites related to biological network, pathways, and functions. The red nodes represent upregulated metabolites, while the green nodes represent downregulated ones. CP represents the signaling pathway related to the changed metabolites