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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Metabonomics profile analysis in inflammation-induced preterm birth and the potential role of metabolites in regulating premature cervical ripening

Fig. 2

Characteristics of PTB mice. A The images display that the pups of PTB mice were immature. B Results of cervical H&E staining of the CTL and PTB groups. Histological slices revealed that there were more CSMC in the CTL group. C CSMC markers and uterine activation protein content in PTB mice changed. PTB mice had a higher level of OR mRNA, the relative mRNA expression of α-SMA, SM-22, and calponin was lower in the PTB group (* p < 0.05). D Immunohistochemistry was used to stain cervical tissues. The slides show that CTL mice cervix contained a significant amount of α-SMA, SM22, and calponin. The content of COX-2, OR, and connexin-43 was higher in PTB mice. E The semi-quantitative analysis of immunohistochemistry slides show that compared with CTL group, the content of α-SMA, SM-22, and calponin were lower, while COX-2,OR and connexin-43 were higher in PTB group (all the differences were statistically significant) (* P < 0.05, n = 5)

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