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Table 1 Baseline characteristics of patients

From: Metabolic syndrome is an independent risk factor for time to complete remission of fertility-sparing treatment in atypical endometrial hyperplasia and early endometrial carcinoma patients

 

Time to CR

P-value

 < 6 m (n = 78)

6-9 m (n = 12)

 > 9 m (n = 16)

Age (years)

31.9 ± 4.3

31.2 ± 3.8

31.4 ± 4.1

0.833

BMI (kg/m2)

25.8 ± 4.4

27.1 ± 5.6

26.9 ± 3.9

0.561

HOMA-IR

3.4 ± 2.7

3.7 ± 2.6

4.8 ± 3.3

0.212

FBG (mmol/L)

5.0 ± 1.0

5.3 ± 1.5

7.0 ± 8.8

0.886

Serum insulin (μU/mL)

15.2 ± 10.5

16.1 ± 10.2

20.0 ± 14.7

0.455

HDL (mmol/L)

1.13 ± 0.02

1.13 ± 0.09

1.23 ± 0.16

0.442

Triglyceride(mmol/L)

1.61 ± 0.12

1.38 ± 0.19

1.90 ± 0.35

0.152

Following time (months)

35.2 ± 29.7

42.0 ± 23.2

34.9 ± 35.1

0.450

IR

   

0.547

 No

41 (52.6%)

6 (50.0%)

6 (37.5%)

 

 Yes

37 (47.4%)

6 (50.0%)

10 (62.5%)

 

DM

   

0.416

 No

61 (78.2%)

8 (66.7%)

14 (87.5%)

 

 Yes

17 (21.8%)

4 (33.3%)

2 (12.5%)

 

HBP

   

1.000

 No

72 (92.3%)

11 (91.7%)

15 (93.8%)

 

 Yes

6 (7.7%)

1 (8.3%)

1 (6.2%)

 

MetS

   

0.187

 No

68 (87.2%)

10 (83.3%)

11 (68.8%)

 

 Yes

10 (12.8%)

2 (16.7%)

5 (31.2%)

 

PCOS

   

0.008

 No

46 (59.0%)

8 (66.7%)

3 (18.8%)

 

 Yes

32 (41.0%)

4 (33.3%)

13 (81.2%)

 

Gestation

   

0.416

 No

45 (57.7%)

9 (75.0%)

11 (68.8%)

 

 Yes

33 (42.3%)

3 (25.0%)

5 (31.2%)

 

Parity

   

0.080

 No

61 (78.2%)

12 (100.0%)

15 (93.8%)

 

 Yes

17 (21.8%)

0 (0.0%)

1 (6.2%)

 

Infertility

   

0.908

 No

42 (53.8%)

7 (58.3%)

8 (50.0%)

 

 Yes

36 (46.2%)

5 (41.7%)

8 (50.0%)

 

Histological type

   

0.227

 AEH

47 (60.3%)

6 (50.0%)

6 (37.5%)

 

 Early EC

31 (39.7%)

6 (50.0%)

10 (62.5%)

 

Metformin

   

0.950

 No

42 (53.8%)

7 (58.3%)

9 (56.2%)

 

 Yes

36 (46.2%)

5 (41.7%)

7 (43.8%)

 

MPA250mg

   

0.448

 No

31 (39.7%)

7 (58.3%)

6 (37.5%)

 

 Yes

47 (60.3%)

5 (41.7%)

10 (62.5%)

 

MPA500mg

   

0.521

 No

63 (80.8%)

8 (66.7%)

13 (81.2%)

 

 Yes

15 (19.2%)

4 (33.3%)

3 (18.8%)

 

MA

   

0.148

 No

68 (87.2%)

9 (75.0%)

11 (68.8%)

 

 Yes

10 (12.8%)

3 (25.0%)

5 (31.2%)

 

GnRH-a

   

0.907

 No

68 (87.2%)

11 (91.7%)

14 (87.5%)

 

 Yes

10 (12.8%)

1 (8.3%)

2 (12.5%)

 

Recurrence

   

0.365

 No

49 (62.8%)

8 (66.7%)

13 (81.2%)

 

 Yes

29 (37.2%)

4 (33.3%)

3 (18.8%)

 
  1. CR Complete remission, 6 m 6 months, 6-9 m Between 6 and 9 months, 9 m 9 months, BMI Body mass index, HOMA-IR Homeostasis model assessment of insulin resistance-insulin resistance, FBG Fasting blood glucose, HDL High-density lipoprotein, IR Insulin resistance, DM Diabetes, HBP High blood pressure, MetS Metabolic syndrome, PCOS Polycystic ovarian syndrome, AEH Atypical endometrial hyperplasia, early EC Early endometrioid adenocarcinoma diagnosed with Grade1, Stage IA, MPA Oral medroxyprogesterone acetate, MA Oral megestrol acetate