Table 2 Preeclampsia prediction relies on 8 increased cfRNA genes and 10 decreased cfRNA genes (Summarized from Moufarrej et al., 2022 [70])
From: Diagnostic biomolecules and combination therapy for pre-eclampsia
Gene trends | Marker gene to quantify | Biological process | Molecular function |
|---|---|---|---|
Enriched in PE | DERA (Deoxyribose-phosphate aldolase) | - Pentose-phophate shunt - Deoxyribose phosphate catabolic process | - Deoxyribose-phosphate aldolase activity - Protein binding |
KIAA 1109 | - Synaptic vesicle endocytosis - Regulation of epithelial cell differentiation - Endosomal transport | - Protein binding | |
NMRK1 (Nicotinamide riboside kinase 1) | - NAD metabolic process - Phosphorylation - NAD biosysnthetic process | - Ribosylnicotinamide kinase activity | |
PI4KA (Phosphatidylinositol 4 kinase alpha) | - Multi-organism membrane organization - Phosphorylation - Viral replication complex formation and maintenance | - Kinase activity - Phosphatidylinasitol kinase activity - Protein binding | |
PRTFDC1 (Phosphoribosyl transferase domain containing 1) | - Guanine salvage - GMP catabolic process - Purine ribonucleoside salvage | - Protein homodimerization activity - Hypoxanthines phosphoribosyltransferase activity | |
Y_RNA | NR | NR | |
Y_RNA | NR | NR | |
YWHAQP5 (YWHAQ pseudogene 5) | NR | NR | |
Decreased in PE | CAMK2G (Calcium/ calmodulin dependent protein kinase II gamma) | - Nervous system development - Protein phopharylation - Regulation of neuron projective development - Regulation of skeletal muscle adaptation | - Calcium-dependent protein serine/ threonine phosphatase activity - Identical protein binding - Protein homodimerization activity |
FAM46A (Terminal mucleotidyltransferase 5A) | - mRNA stabilization - Response to bacterium | - RNA adenynltransferase activity - Protein binding - RNA binding | |
LRRC58 (Leucine rich repeat containing 58) | NR | NR | |
MYLIP (Myosin regulatory light chain interacting protein) | - Nervous system development - Regulation of low-density lipoprotein particle receptor catabolic process | - Ubiquitin protein ligaseactivity - Cytoskeletal protein binding - Protein binding - Metal ion binding | |
NDUFV3 (NADH: ubiquinone oxidoreductase subunit V3) | - Mitochondrial electron transport - NADH to ubiquinone | - NADH dehydrogenase activity - Protein binding - RNA binding | |
PYGO2 (Pygopus family PHD finger 2) | - Positive regulation of chromatin binding - Developemental growth - Regulation of histone H3-K4 methylation - Mammary gland development | - Chromatin binding - Protein binding - Metal ion binding - Histone acetyltransferase regulator activity - Histone binding | |
RNF149 (Ring finger protein 149) | - Ubiquitin-dependent protein catabolic process - Regulation of protein stability - Protein ubiquitination | - Ubiquitin protein ligase activity - Metal ion binding | |
TFIP11 (Tuftelin interacting protein 11) | - Biomineral tissue development - Negative regulation of protein binding - Spliceosomal complex disassembly | - Protein binding - Nucleic acid binding | |
TRIM21 (Tripartite motif containing 21) | - Negative regulation of protein deubiquitination - Regulation of protein localization - Regulation of gene expression | - Zinc ion binding - Transcription coactivator activity - Identical protein binding | |
USB1 (U6 snRNA biogenesis phosphodiesterase 1) | - U6 snRNA 3’-end processing - RNA splicing | - Poly (U)-specific exoribonuclease activity |