Table 1 Application of cffDNA associated genes in PE prediction
From: Diagnostic biomolecules and combination therapy for pre-eclampsia
Marker gene to quantify | Gestational age (in weeks) | Results in PE prediction |
|---|---|---|
Hypermethylated RASSF1A | 8–17 | cffDNA concentration at cutoff value of 7.49 GE/ml showing 100% sensitivity and 50% specificity [60] |
11–13 | cffDNA concentration at cutoff value of 512 GE/ml showing 100% sensitivity and 50% specificity [60] | |
15–28 | cffDNA concentration increased 3.3-fold [59] | |
21- 40 | The positive correlations of hypermethylated RASSF1A with PAPP-A, PP-13 and urine protein in PE [59] | |
DSCR3, RASSF1A, HYP2 | 6–14 | The combination of DSCR3, RASSF1A, HYP2 and PAPP-A with 66.9% of detection rate at 10% of FPR [58] |
Y chromosome specific gene | 15–20 | cffDNA concentration at cutoff value of 2.62 GE/ml showing 90% sensitivity and 85% specificity for early-onset PE [64] |