Fig. 2

The analysis of expression level in NOA, OA and healthy samples. A Primary component analyze. The X, Y and Z axis represents the three main factors which affected the expression level of the sample. The colored point represents the corresponding sample, and the location of it shows the main character of the sample. Space distance represents the similarity of data size. The volcano plot of differentially expressed tsRNAs between NOA and OA patients (B) and between NOA patients and healthy people (C). The values of X and Y axes in the volcano plot are log2 transformed fold change and -log10 transformed p-values between the two groups, respectively. Red/Green circles indicate statistically significant differentially expressed tsRNAs with fold change no less than 1.5 and p-value ⩽ 0.05 (Red: up-regulated; Green: down-regulated). Gray circles indicate non-differentially expressed tsRNAs, with FC and/or q-value are not meeting the cutoff thresholds