The role of insulin-like growth factor 2 mRNA binding proteins in female reproductive pathophysiology

Xu, Xiao; Shen, Hao-Ran; Zhang, Jia-Rong; Li, Xue-Lian

doi:10.1186/s12958-022-00960-z

Reproductive Biology and Endocrinology

Table 1 The role of IMPs in the embryogenesis, oocyte maturation, and female reproductive pathology

From: The role of insulin-like growth factor 2 mRNA binding proteins in female reproductive pathophysiology

Condition		Cell type/Species	Key findings	Proposed mediator	Implications	References
Embryogenesis	MTZ	Zebrafish oocyte	IMP3 ↓ leads to abnormal cytoskeleton organization and cell division	Maternal mRNAs	IMP3 depletion leads to severe developmental defects	[45]
	MTZ	Zebrafish oocyte	IMP3 ↑ inhibits maternal-to-zygotic transition	Maternal mRNAs	Leads to developmental delay	[46]
	ZGA	Mice	IMP2 ↓causes early embryonic developmental arrest	Ccar1, Rps14, IGF2	Abundant IMP2 is essential for the embryo development	[38]
	Implantation	Human/Bovine	Methylation ratio of IMP2↓and IMP3 ↑in receptive endometrium	No data	Predicts the estrous phase	[49, 50]
	Placentation	Human	IMP1 and IMP3 ↑	Corresponding receptors	Early dialogue between blastocysts and maternal endometrial cells	[16]
	Placentation	Ovine	IMP1-3↓	LIN28, let-7	Increases the degree of elongation of the conceptus abnormal m6A modification	[64]
	PA	Mice	The expression of IMP1 and IMP2 is perturbed	No data	during early development in PA embryos	[65]
	PA	Mice	IMP1↓	miR-670	Regulates RNA methylation in PA mouse embryonic development	[66]
Oocyte maturation		Zebrafish oocyte	IMP3 retards the progression of oocyte maturation	Cyclin B1	Represses oocyte maturation	[71]
PCOS		Human	IMP2↓in cumulus cells from PCOS patients	No data	Predictive biomarker	[69]
PCOS		Human	IMP2↑in GCs and ovary	CCND2, SERBP1	Provides new insights into the dysfunction of GCs in PCOS	[18]
PE		HTR-8/Svneo cells	IMP1 inhibits apoptosis in HTR-8/Svneo cells	miR-423-5p	A new light on the pathogenesis of severe pre-eclampsia	[21]
		HTR-8/Svneo cells	IMP2 promotes the invasion and migration of HTR-8/Svneo cell	miR-181a-5p	The roles and molecular mechanisms of IMP2 in PE	[20]
		Human placenta	IMP3 ↓in the placentas from PE patients	IGF2, CD44	Predictive biomarker	[19]
GDM		Human	Rs4402960 (IMP2)	No data	Associated with a higher risk of GDM	[86,87,88]
Gynecological oncology	ULM/ULMS	Human	IMP2/IMP3	No data	Predictive marker/independent prognostic factor	[105, 108]
	Cervical carcinoma	SiHa cells	IMP3 ↑ facilitate cell aerobic glycolysis	Hexokinase 2	A potential approach for cervical cancer therapeutics	[109]
	Choriocarcinoma	JAR cells	IMP1 ↑ promotes cell migration and invasion	RSK2, PPME2	Aggravating the choriocarcinoma disease progression	[52]
	Endometrial carcinoma	Human	IMP3 ↑, PR, L1CAM	No data	Histological subtyping in high-grade EECs	[112]
	Ovarian carcinoma	Human	IMP1, IMP2, IMP3 and E-cadherin	No data	Predicts disease recurrence and survival	[97,98,99]

Abbreviation: MTZ Maternal-to-zygotic transition, ZGA Zygotic genome activation, PA Parthenogenetic activation, PCOS Polycystic ovary syndrome, PE Pre-eclampsia, GDM Gestational diabetes mellitus, ULM Uterine leiomyomas, ULMS Uterine leiomyomasarcoma

Back to article page

ISSN: 1477-7827

Contact us

General enquiries: journalsubmissions@springernature.com