Skip to main content
Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells

Fig. 6

Overexpression of UFL1 in cultured ovaries alleviates apoptosis and dysfunction induced by cisplatin. A The efficiency of UFL1 overexpression was detected by western blot. B Follicles were observed after HE staining and follicles of all stages were counted in tissue slices. Bar, 20 μm. Primordial follicle (I), primary follicle (II), secondary follicle (III), atretic follicle (IV). C, D The rate of follicle atresia and the primordial follicular rate vs. the total number of follicles in each group. E Changes in UFL1, FSHR and AMH protein levels with cisplatin treatment in UFL1 overexpressing ovaries. F Changes in the BAX, BCL-2, cleaved caspase-3 and caspase-3 proteins in UFL1-overexpressing ovaries treated with cisplatin. n ≥ 3 for each group. * p < 0.05; ** p < 0.01; *** p < 0.001 compared with the control group. # p < 0.05; ## p < 0.01; ### p < 0.001 compared with the cisplatin treatment group

Back to article page