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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells

Fig. 5

Loss of UFL1 led to activation of ovarian ER stress, increased atretic follicles, and decreased ovarian function. A Changes in the protein level of UFL1 in UFL1 knockdown ovaries. B Changes in the protein levels of UFL1, FSHR and AMH. C E2 levels in ovarian homogenate after UFL1 knockdown. D-E Follicles were observed after HE staining, and follicles of all stages were in tissue slices. Bar, 50 μm. Primordial follicle (I), primary follicle (II), secondary follicle (III), atretic follicle (IV). (F, G) The rate of follicle atresia and the primordial follicular rate vs. the total number of follicles in each group. H Changes in UFL1 protein and the ER stress markers GRP78, XBP1s and CHOP. I Changes in the proteins UFL1, BAX, BCL-2, cleaved caspase-3 and caspase-3. n ≥ 3 for each group. * p < 0.05; ** p < 0.01; *** p < 0.001 compared with the control group. # p < 0.05; ## p < 0.01; ### p < 0.001 compared with the cisplatin treatment group

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