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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Ubiquitin-like modifier 1 ligating enzyme 1 relieves cisplatin-induced premature ovarian failure by reducing endoplasmic reticulum stress in granulosa cells

Fig. 1

The expression of UFL1 decreased in POF model mouse ovaries and GCs. A The protein level of UFL1 in mouse ovaries at 1D, 7D, 2 W, 2 M, and 10 M. B The UFL1 and FSHR protein level in POF ovaries. C IHC to detect UFL1 in POF ovaries. Bar, 20 μm. Primordial follicle (I), primary follicle (II), secondary follicle (III), atretic follicle (IV). D IF to detect UFL1 in primary GCs. Bar, 20 μm. E The level of UFL1 in GCs treated with different concentrations of cisplatin. F, G The protein and mRNA levels of UFL1 in GCs treated with 20 μM cisplatin for different durations. n ≥ 3 for each group. * p < 0.05; ** p < 0.01; *** p < 0.001 compared with the control group

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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