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Table 5 Association of cSLE with adverse pregnancy outcomes

From: Characteristics of childhood-onset systemic lupus erythematosus in pregnancy and its association with pregnancy outcomes: a retrospective comparative cohort study

Pregnancy outcomes

cSLE

aSLE

OR (95%CI)

P value

Composite adverse foetal outcomes (N = 97)

 Unadjusted

2.107 (0.780–5.692)

0.142

1 (reference)

 Model 1a

2.496 (0.653–9.542)

0.181

1 (reference)

 Model 1b

2.285(0.549–9.503)

0.256

1 (reference)

Composite adverse live-birth outcomes (N = 58)

 Unadjusted

1.707 (0.556–5.237)

0.350

1 (reference)

 Model 2a

1.348 (0.410–4.434)

0.623

1 (reference)

 Model 2b

1.417 (0.419–4.789)

0.575

1 (reference)

Composite adverse maternal outcomes (N = 46)

 Unadjusted

2.667 (0.863–8.237)

0.088

1 (reference)

 Model 3a

2.891 (0.917–9.117)

0.070

1 (reference)

 Model 3b

3.057 (0.936–9.986)

0.064

1 (reference)

  1. Model 1a: gestational age, SLE duration, and SLE in remission for < 6 months before pregnancy; model 1b: model 1a + haematologic disorders, low complement level, and aspirin
  2. Model 2a: gestational age, and SLE in remission for < 6 months before pregnancy; model 2b: model 2a + haematologic disorders
  3. Model 3a: pre-pregnancy BMI, and SLE in remission for < 6 months before pregnancy; model 3b: model 3a + haematologic disorders
  4. cSLE childhood-onset systemic lupus erythematosus, OR odds ratio, CI confidence interval