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Table 4 Comparison of pregnancy outcomes between the cSLE and aSLE groups

From: Characteristics of childhood-onset systemic lupus erythematosus in pregnancy and its association with pregnancy outcomes: a retrospective comparative cohort study

Pregnancy outcomes

cSLE

aSLE

P value

Foetal outcomes

N = 22

N = 145

 

 Composite adverse foetal outcomes

16 (72.7%)

81 (55.9%)

0.135

 Foetal loss

8 (36.4%)

31 (21.4%)

0.122

 Foetal loss (without therapeutic/elective abortion)

0/14 (0.0%)

14/128 (10.9%)

0.406

Live birth outcomes

N = 14

N = 114

 

 Composite adverse live-birth outcomes

8 (57.1%)

50 (43.9%)

0.346

 Preterm birth

2 (14.3%)

27 (23.7%)

0.649

 Foetal distress

1 (7.1%)

2 (1.8%)

0.296

 FGR

1 (7.1%)

9 (7.9%)

1.000

 LBW

4 (28.6%)

33 (28.9%)

1.000

 SGA

4 (28.6%)

24 (21.1%)

0.764

 Asphyxiation

2 (14.3%)

9 (7.9%)

0.764

Maternal outcomes

N = 14

N = 114

 

 Composite adverse maternal outcomes

8 (57.1%)

38 (33.3%)

0.080

 Active SLE

7 (50.0%)

19 (16.7%)

0.010

 Active LN

7 (50.0%)

16 (14.0%)

0.003

 HDP

1 (7.1%)

15 (13.2%)

0.830

 GDM

0 (0.0%)

12 (10.5%)

0.430

 PPH

1 (7.1%)

3 (2.6%)

0.374

  1. SLE systemic lupus erythematosus, LN lupus nephritis, cSLE childhood-onset systemic lupus erythematosus, aSLE adult-onset systemic lupus erythematosus, FGR foetal growth restriction, LBW low birth weight, SGA small for gestational age, HDP hypertensive disorders in pregnancy, GDM gestational diabetes mellitus, PPH postpartum haemorrhage