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Table 5 Discrimination of embryo morphology to predict the cycle with blastocyst in different patient subgroup

From: Does conventional morphological evaluation still play a role in predicting blastocyst formation?

Subgroup

n

Prevalence (95%CI)

AUC (95%CI)

Threshold

Sensitivity (95%CI)

Specificity (95%CI)

PPV (95%CI)

NPV (95%CI)

Accuracy (95%CI)

Overall

1956

0.89(0.88–0.9)

0.93(0.92–0.94)

predicted embryo1

0.92(0.9–0.93)

0.7(0.64–0.76)

0.96(0.95–0.97)

0.5(0.45–0.56)

0.89(0.88–0.91)

cumulative p0.9

0.85(0.83–0.87)

0.88(0.83–0.92)

0.98(0.98–0.99)

0.41(0.37–0.46)

0.85(0.84–0.87)

cumulative p0.8

0.91(0.9–0.92)

0.74(0.68–0.8)

0.97(0.96–0.97)

0.5(0.44–0.56)

0.89(0.88–0.9)

cumulative p0.7

0.95(0.94–0.96)

0.6(0.53–0.66)

0.95(0.94–0.96)

0.59(0.52–0.65)

0.91(0.9–0.92)

cumulative p0.6

0.96(0.95–0.97)

0.51(0.44–0.58)

0.94(0.93–0.95)

0.62(0.55–0.69)

0.91(0.9–0.93)

cumulative p0.5

0.98(0.97–0.98)

0.39(0.33–0.46)

0.93(0.92–0.94)

0.66(0.58–0.74)

0.91(0.9–0.92)

Embryo cultured < 4

624

0.71(0.67–0.74)

0.81(0.78–0.85)

predicted embryo1

0.68(0.63–0.72)

0.77(0.71–0.83)

0.88(0.84–0.91)

0.5(0.44–0.55)

0.7(0.67–0.74)

cumulative p0.9

0.5(0.46–0.55)

0.92(0.88–0.96)

0.94(0.91–0.97)

0.44(0.39–0.48)

0.63(0.59–0.66)

cumulative p0.8

0.68(0.64–0.72)

0.79(0.73–0.85)

0.89(0.85–0.92)

0.51(0.45–0.56)

0.71(0.68–0.75)

cumulative p0.7

0.81(0.77–0.84)

0.65(0.58–0.72)

0.85(0.81–0.88)

0.58(0.52–0.65)

0.76(0.73–0.79)

cumulative p0.6

0.85(0.82–0.89)

0.56(0.49–0.63)

0.82(0.79–0.86)

0.62(0.54–0.69)

0.77(0.74–0.8)

cumulative p0.5

0.91(0.88–0.93)

0.43(0.36–0.5)

0.79(0.76–0.83)

0.66(0.57–0.74)

0.77(0.73–0.8)

Female age35

461

0.82(0.78–0.85)

0.91(0.88–0.94)

predicted embryo1

0.89(0.86–0.92)

0.72(0.62–0.81)

0.93(0.91–0.96)

0.6(0.5–0.69)

0.86(0.83–0.89)

cumulative p0.9

0.82(0.79–0.86)

0.87(0.8–0.94)

0.97(0.95–0.99)

0.53(0.45–0.61)

0.83(0.8–0.87)

cumulative p0.8

0.89(0.86–0.92)

0.73(0.63–0.82)

0.94(0.91–0.96)

0.6(0.51–0.7)

0.86(0.83–0.89)

cumulative p0.7

0.94(0.92–0.97)

0.58(0.47–0.68)

0.91(0.88–0.94)

0.7(0.59–0.81)

0.88(0.85–0.91)

cumulative p0.6

0.95(0.93–0.97)

0.44(0.33–0.54)

0.88(0.85–0.91)

0.67(0.55–0.8)

0.86(0.82–0.89)

cumulative p0.5

0.98(0.97–1)

0.33(0.23–0.43)

0.87(0.83–0.9)

0.82(0.7–0.95)

0.86(0.83–0.89)

Without good embryo

279

0.51(0.45–0.57)

0.74(0.68–0.79)

predicted embryo1

0.43(0.35–0.51)

0.85(0.78–0.91)

0.75(0.65–0.84)

0.59(0.52–0.66)

0.63(0.58–0.69)

cumulative p0.9

0.19(0.12–0.25)

0.98(0.95–1)

0.9(0.79–1.01)

0.53(0.47–0.6)

0.57(0.52–0.63)

cumulative p0.8

0.36(0.28–0.44)

0.91(0.86–0.96)

0.81(0.72–0.91)

0.58(0.51–0.64)

0.63(0.57–0.69)

cumulative p0.7

0.53(0.45–0.61)

0.84(0.78–0.9)

0.78(0.69–0.86)

0.63(0.56–0.7)

0.68(0.63–0.74)

cumulative p0.6

0.59(0.51–0.67)

0.77(0.7–0.84)

0.73(0.65–0.81)

0.64(0.57–0.71)

0.68(0.62–0.73)

cumulative p0.5

0.73(0.65–0.8)

0.62(0.54–0.7)

0.67(0.59–0.74)

0.68(0.6–0.77)

0.67(0.62–0.73)

Partial embryo cultured

863

0.81(0.78–0.84)

0.87(0.84–0.9)

predicted embryo1

0.84(0.81–0.87)

0.72(0.65–0.78)

0.93(0.91–0.95)

0.51(0.45–0.58)

0.81(0.79–0.84)

cumulatvie p0.9

0.68(0.65–0.72)

0.9(0.85–0.94)

0.97(0.95–0.98)

0.4(0.35–0.45)

0.72(0.69–0.75)

cumulatvie p0.8

0.82(0.79–0.85)

0.78(0.72–0.84)

0.94(0.92–0.96)

0.51(0.45–0.57)

0.81(0.79–0.84)

cumulatvie p0.7

0.9(0.87–0.92)

0.62(0.55–0.7)

0.91(0.89–0.93)

0.59(0.51–0.66)

0.84(0.82–0.87)

cumulatvie p0.6

0.92(0.9–0.94)

0.53(0.46–0.61)

0.89(0.87–0.92)

0.61(0.53–0.69)

0.85(0.82–0.87)

cumulatvie p0.5

0.95(0.94–0.97)

0.42(0.35–0.5)

0.87(0.85–0.9)

0.67(0.58–0.76)

0.85(0.83–0.87)