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Table 3 Discrimination of different models in predicting blastocyst formation

From: Does conventional morphological evaluation still play a role in predicting blastocyst formation?

 

Training set

Validation set

Model

AUC (95%CI)

Cutoff

Sensitivity(95%CI)

Specificity (95%CI)

PPV(95%CI)

NPV(95%CI)

Accuracy(95%CI)

AUC (95%CI)

PPV(95%CI)

NPV(95%CI)

Accuracy(95%CI)

GEEa

0.771(0.768–0.774)

0.51

0.804(0.801–0.808)

0.625(0.62–0.629)

0.743(0.739–0.746)

0.703(0.698–0.708)

0.728(0.725–0.731)

0.779(0.77–0.787)

0.761(0.751–0.77)

0.721(0.707–0.735)

0.747(0.739–0.755)

LASSOb

0.775(0.772–0.778)

0.55

0.793(0.789–0.796)

0.636(0.631–0.64)

0.746(0.742–0.749)

0.695(0.69–0.699)

0.726(0.723–0.729)

0.78(0.771–0.789)

0.77(0.761–0.78)

0.699(0.686–0.713)

0.744(0.736–0.752)

Xgboostb

0.783(0.78–0.785)

0.57

0.8(0.796–0.803)

0.635(0.63–0.639)

0.747(0.743–0.75)

0.701(0.697–0.706)

0.729(0.726–0.732)

0.754(0.745–0.763)

0.773(0.763–0.783)

0.645(0.632–0.659)

0.719(0.711–0.727)

  1. amodel includes embryo morphology only
  2. bmodel includes following features in combination with embryo morphology: female age, male age, GnRH analogues, insemination protocol, TESA/PESA, maternal height, maternal weight, maternal BMI, maternal basal FSH, maternal basal LH, maternal basal PRL, maternal basal E2, maternal basal T, basal AFC, gonadotropin dose, gonadotropin duration, HMG dose, HMG duration, starting dose, FSH on the day of stimulation, LH on the day of stimulation, E2 on the day of stimulation, E2 on the day of triggering, LH on the day of triggering, P on the day of triggering, oocyte yield, and maturation rate of oocytes in the cycle