Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression

Table 3 Correlations between FMR1 and AKT/mTOR signaling pathway genes

All patients	Spearman correlation coefficient (ρ) for FMR1	p
AKT	0.136	0.122
mTOR	0.533	< 0.001
S6K	0.551	< 0.001
TSC2	0.217	0.013
Patients with POI
AKT	0.059	0.615
mTOR	0.602	< 0.001
S6K	0.746	< 0.001
TSC2	0.191	0.104
FCs
AKT	0.177	0.193
mTOR	0.388	0.003
S6K	0.288	0.031
TSC2	0.213	0.115

Correlation between FMR1 and AKT/mTOR signaling pathway genes in all women, followed by subgroup analysis. Abbreviations: POI premature ovarian insufficiency, FCs fertile controls

ISSN: 1477-7827