Activation of AKT/mammalian target of rapamycin signaling in the peripheral blood of women with premature ovarian insufficiency and its correlation with FMR1 expression

Table 2 Expression of FMR1, AKT1, TSC2, mTOR, and S6K premutation vs non-premutation carriers

POI	POI without PM	POI with PM^b	P^a
n	67	5
FMR1	3.499 (2.433–4.484)	5.376 (4.314–6.133)	0.011
AKT1	4.807 (4.081–5.564)	3.407 (3.305–5.401)	0.231
TSC2	3.730 (3.052–4.107)	2.494 (1.212–3.721)	0.141
mTOR	2.550 (1.878–3.917)	2.769 (1.543–4.138)	1.000
S6K	1.745 (1.555–2.218)	2.370 (2.291–2.909)	0.046

Relative Expression of FMR1, AKT1, TSC2, mTOR, and S6K in patients with premature ovarian insufficiency with and without FMR1 premutation. Abbreviations: PM permutation, POI premature ovarian insufficiency. Data are shown as medians (25^th–75^th percentiles). ^aMann-Whitney tests. ^bPremutated alleles (n); range, 70–81 repeats

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