Table 1 AKT1, TSC2, mTOR, and S6K expression in patients with premature ovarian insufficiency vs. fertile controls

Gene

Median (25^th to 75^th percentiles)

Median (25^th to 75^th percentiles)

p^a

FMR1

3.539 (2.487–4.594)

3.400 (2.374–4.373)

0.382

AKT1

4.797 (3.972–5.553)

3.590 (1.724–5.342)

0.009

TSC2

3.678 (2.942–4.077)

2.917 (1.269–3.691)

0.001

mTOR

2.533 (1.819–3.996)

1.856 (0.517–3.255)

0.002

S6K

1.824 (1.564–2.281)

1.538 (0.574–2.029)

0.001