Fig. 7

Significant interactions between predicted upstream hormone regulators and protein changes for EP vs. IUP. a. Left: network of progesterone regulated proteins in EP vs. IUP trophoblast specimens and heatmap showing related protein changes for pairwise comparisons in both tissues. Right: progesterone receptor (PGR) network and corresponding heatmap. b. Networks and heatmap for chorionic gonadotropin (CG) regulated proteins identified in the trophoblast and decidua. c. Networks and heatmap of estrogen receptor regulated proteins identified in the trophoblast and decidua. On heatmaps: red asterisks indicate activated (z-score ≥ 2; orange highlight in box) or inhibited (z-score ≤  − 2; blue highlight in box) upstream regulators. Increased and decreased protein changes are highlighted in red and green. T: trophoblast; D: decidua. Other network and prediction parameters are defined in the network legend