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Table 1 Maternal characteristics of all pregnancies in Sweden (2006—2016) categorized by presence or absence of polycystic ovary syndrome (PCOS) and use of metformin

From: Pregnancy, perinatal and childhood outcomes in women with and without polycystic ovary syndrome and metformin during pregnancy: a nationwide population-based study

  PCOS (−)
Metformin (−)
n (%)
PCOS (−)
Metformin (+)
n (%)
PCOS (+)
Metformin (−)
n (%)
PCOS (+)
Metformin (+)
n (%)
994,102 870 21,486 347
Maternal age
  < 25 142,228 (14.3) 58 (6.7) 2875 (13.4) 34 (9.8)
25–29 296,675 (29.8) 185 (21.3) 7108 (33.1) 105 (30.3)
30–34 338,465 (34) 305 (35.1) 7547 (35.1) 122 (35.2)
  ≥ 35 216,734 (21.8) 322 (37.0) 3956 (18.4) 86 (24.8)
Maternal BMI (Kg/m2)
  < 20 103,661 (10.4) 14 (1.6) 1600 (7.4) 9 (2.6)
20–24.9 518,187 (52.1) 152 (17.5) 8462 (39.4) 60 (17.3)
25–29.9 249,843 (25.1) 234 (26.9) 6022 (28) 92 (26.5)
  ≥ 30 122,411 (12.3) 470 (54) 5402 (25.1) 186 (53.6)
Parity
Multiparous 556,148 (55.9) 555 (63.8) 10,332 (48.1) 149 (42.9)
Primiparous 437,954 (44.1) 315 (36.2) 11,154 (51.9) 198 (57.1)
Cigarette Consumption
Yes 59,804 (6) 47 (5.4) 1228 (5.7) 20 (5.8)
No 934,298 (94) 823 (94.6) 20,258 (94.3) 327 (94.2)
Assisted Reproduction
Yes 28,376 (2.9) 53 (6.1) 2357 (11) 34 (9.8)
No 965,726 (97.1) 817 (93.9) 19,129 (89) 313 (90.2)
Diabetes Mellitus
Yes 5695 (0.6) 273 (31.4) 304 (1.4) 49 (14.1)
No 988,407 (99.4) 597 (68.6) 21,182 (98.6) 298 (85.9)
Gestational Diabetes
Yes 11,578 (1.2) 282 (32.4) 559 (2.6) 26 (7.5)
No 982,524 (98.8) 588 (67.6) 20,927 (97.4) 321 (92.5)
  1. Abbreviations: BMI Body mass index