Table 1 Analyses of primary outcomes between SET and DET in a single cycle

Overall

62

85,988

247,116

91%

0.78 (0.71-0.85)

< 0.001

45

17,979

49,645

2%

0.05 (0.04-0.06)

< 0.001

Maternal age (years)

0.504^*

0.035^*

   < 35^a

12

20,637

27,263

85%

0.71 (0.61-0.84)

< 0.001

11

5061

12,322

0%

0.03 (0.03-0.05)

< 0.001

  35-40

6

11,009

20,285

69%

0.80 (0.69-0.94)

0.005

5

3767

15,100

0%

0.04 (0.03-0.06)

< 0.001

   ≥ 40

4

2584

3395

69%

0.87 (0.54-1.40)

0.565

3

347

528

0%

0.34 (0.06-2.03)

0.236

Quality

–

–

  G/GG

7

7293

24,514

82%

0.63 (0.52-0.77)

< 0.001

10

4698

3665

57%

0.06 (0.03-0.10)

< 0.001

  G/GP

8

7601

3308

81%

0.99 (0.77-1.27)

0.915

9

4648

1470

66%

0.12 (0.06-0.26)

< 0.001

  P/PP

3

786

681

0%

0.57 (0.45-0.71)

< 0.001

6

381

429

54%

0.23 (0.04-1.49)

0.123

Embryo stage

0.116^*

0.28^*

  Cleavage

32

40,348

140,827

96%

0.67 (0.55-0.82)

< 0.001

17

5681

32,187

0%

0.06 (0.04-0.08)

< 0.001

  Blastocyst

25

39,455

93,424

88%

0.81 (0.71-0.92)

0.001

22

9308

14,928

25%

0.05 (0.04-0.06)

< 0.001

Cycle

0.608^*

0.712^*

  Fresh

53

77,288

217,979

91%

0.80 (0.72-0.88)

< 0.001

36

14,391

45,104

0%

0.05 (0.05-0.07)

< 0.001

  Frozen

10

8541

28,928

89%

0.74 (0.59-0.94)

0.013

7

3057

3885

48%

0.05 (0.03-0.09)

< 0.001

Design

< 0.001^*

0.73^*

  RCT

13

1044

1050

0%

0.53 (0.44-0.63)

< 0.001

5

222

234

0%

0.06 (0.02-0.21)

< 0.001

 Observational study

49

84,944

246,066

93%

0.82 (0.75-0.90)

< 0.001

40

17,757

49,411

11%

0.05 (0.04-0.06)

< 0.001

Adjusted

12

6921

28,828

41%

0.77 (0.68-0.87)

< 0.001

4

797

1847

0%

0.06 (0.02-0.16)

< 0.001

First cycle

21

76,470

235,620

96%

0.70 (0.61-0.81)

< 0.001

10

11,000

41,814

54%

0.05 (0.03-0.07)

< 0.001

eSET

35

31,189

29,418

70%

0.80 (0.72-0.89)

< 0.001

27

4245

5522

0%

0.05 (0.03-0.07)

< 0.001