Gonadotropin-releasing hormone agonist downregulation combined with hormone replacement therapy improves the reproductive outcome in frozen–thawed embryo transfer cycles for patients of advanced reproductive age with idiopathic recurrent implantation failure

Table 3 Multivariate logistic regression analysis of factors related to pregnancy outcomes of FET

Clinical indicators	Clinical pregnancy rate		Ongoing pregnancy rate
Value	OR value (95% CI)	P value	OR value (95% CI)	P value
Female age(y)	0.868 (0.796-0.947)	0.001*	0.813 (0.738-0.896)	0.000*
Fertilization type
IVF	Ref.		Ref.
ICSI	0.815 (0.536-1.241)	0.340	0.867 (0.547-1.376)	0.546
IVF + ICSI	0.579 (0.159-2.104)	0.406	1.072 (0.286-4.022)	0.918
Endometrial thickness on the day of transfer (mm)	1.059 (0.952-1.179)	0.291	1.026 (0.913-1.152)	0.669
No. of transferred embryos
1	Ref.		Ref.
2	2.495 (1.642-3.791)	0.000*	2.974 (1.853-4.773)	0.000*
3	1.92 (0.763-4.832)	0.166	1.754 (0.579-5.306)	0.320
Type of embryo transferred
Cleavage stage embryo	Ref.		Ref.
Blastocyst	2.047 (1.388-3.02)	0.000*	2.263 (1.479-3.461)	0.000*
Endometrial Preparation Protocols
GnRH agonist-HRT	Ref.		Ref.
HRT	0.664 (0.446-0.987)	0.043*	0.573 (0.369-0.891)	0.013*
NC	0.439 (0.235-0.822)	0.010*	0.414 (0.202-0.846)	0.016*
Clinical indicators	Live birth rate
Value	OR value(95% CI)	P value
Female age(y)	0.819 (0.742-0.903)	0.000 *
Fertilization type
IVF	Ref.
ICSI	0.884 (0.555-1.409)	0.605
IVF + ICSI	1.119 (0.298-4.204)	0.868
Endometrial thickness on the day of transfer (mm)	1.057 (0.94-1.188)	0.352
No. of transferred embryos
1	Ref.
2	3.032 (1.877-4.897)	0.000 *
3	1.89 (0.622-5.742)	0.261
Type of embryo transferred
Cleavage stage embryo	Ref.
Blastocyst	2.28 (1.485-3.5)	0.000 *
Endometrial Preparation Protocols
GnRH agonist-HRT	Ref.
HRT	0.594 (0.381-0.926)	0.021 *
NC	0.38 (0.181-0.796)	0.010 *

*P < 0.05 for logistic regression
Abbreviations: OR Odds ratio; CI 95% Confidence interval; IVF In vitro fertilization; ICSI Intracytoplasmic sperm injection

ISSN: 1477-7827