Fig. 3
From: Therapeutic options for premature ovarian insufficiency: an updated review
Stem cell therapy mechanisms in primary ovarian insufficiency. During ovarian insufficiency, stem cells play multiple roles through homing, differentiation and paracrine stimulation. Paracrine signaling is the key for the improvement of damaged ovaries through anti-apoptosis, anti-fibrotic, angiogenesis, anti-inflammation, and immune regulation. In addition,stem cell-mediated exosomes and mitochondrial transfer demonstrate another novel mechanism