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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome

Fig. 1

The high expression of circ_FURIN in ovarian cortex tissues of PCOS patients. A Circ_FURIN was generated via exon 16 circularization of the FURIN gene, and its presence was validated by qRT-PCR, followed by Sanger sequencing. B and C Circ_FURIN expression was detected by qRT-PCR in lesion ovarian cortex tissues of PCOS patients (N = 21), healthy ovarian cortex tissues (N = 13), mock KGN cells, and the KGN cells treated with TTR (1 and 10 μM). D Cytoplasmic and nuclear circ_FURIN analysis. E and F The stability of circ_FURIN was identified by RNase R and Actinomycin D treatment assays. Statistical significances were compared by Wilcoxon rank-sum test in (B), one-way analysis of variance with Tukey’s test in (C) and Student’s t-tests in (E and F). *P < 0.05

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