Fig. 1

Scatterplot of endoglin, sFlt-1 and vitamin D levels reported as gestational age and body mass index (BMI) adjusted multiples of the median (MoM) in both those pregnancies with preeclampsia and controls (without preeclampsia). The two pregnancy outcome groups are shown on the x-axis with the endoglin, sflt-1 and vitamin D MoM levels on the logarithmic y-axis. Within each group, the data are randomly dithered horizontally to reduce overlap. The size of the symbols indicate the weighting values and have been stratified into five levels. The smallest to largest circles have weights between 0.02 and 0.19, 0.20 to 0.69, 0.70 to 0.89, 0.90 to 0.99 and > 1.00, respectively. The bolding of the symbols indicate the pregnancy delivery prior to 36 weeks gestation. By definition, the controls have a median MoM of 1.00. The weighted median MoM levels for the pregnancies with preeclampsia groups for the three markers are 2.50. 2.11 and 0.88 MoM. The smaller symbols tend to be associated with gestational ages at delivery under 30 weeks