Fig. 1

Identification of a homozygous mutation of SLO3 in a Chinese man with asthenoteratozoospermia. A A homozygous missense mutation of SLO3 (c.1237A > T), was identified in the proband from consanguineous family A-132. The amino acid alteration was predicted according to the verified alteration of cDNA. B The SLO3 gene resides on chromosome 8, and the SLO3 point mutation is located at the conserved site in the RCK domain. C Structure model of wild-type SLO3 protein (in silvery) and the mutant p. Ile (in blue) 413Phe (in red). The mutant residue (in red) is buried in the core of the RCK domain (in yellow). The mutant residue is bigger, probably not fitting and disturbing the core structure of this domain