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Fig. 1 | Reproductive Biology and Endocrinology

Fig. 1

From: Increased METTL3-mediated m6A methylation inhibits embryo implantation by repressing HOXA10 expression in recurrent implantation failure

Fig. 1

Increased m6A RNA methylation and METTL3 expression in RIF endometrial tissues. a The levels of m6A RNA methylation in the endometrial tissues from RIF patients (n=9) and normal control women (n=8) were evaluated by the m6A RNA Methylation Assay Kit. b The m6A levels in the endometrial tissues from RIF patients (n=6) and health control women (n=6) were evaluated by dot blotting assay. c The mRNA levels of major m6A methyltransferases (METTL3, METTL14, RBM15, WTAP and VIRMA) and demethylases (FTO and ALKBH5) in the endometrial tissues from RIF patients (n=13) and normal control women (n=13) were detected by qRT-PCR. d The protein levels of METTL3 in the endometrial tissues from RIF patients (n=8) and normal control women (n=4) were detected by Western blotting. *P<0.05, **P<0.01, ***P<0.001compared with the controls

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