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Fig. 7 | Reproductive Biology and Endocrinology

Fig. 7

From: The inhibitory effect of AMP-activated protein kinase (AMPK) on chemokine and prostaglandin production in human endometrial stromal cells

Fig. 7

The levels of IL-8 (A), MCP-1 (B), PGE2 (C) and PGF2α (D) in culture media of ESCs after 24 h of stimulation with IL-1β, IL-1 receptor antagonist, AICAR and AMPK inhibitor (compound C). The ESCs were treated with human IL-1β (1 nM), IL-1ra (10 nM), AICAR (3 mM) and compound C (10 μM). *P < 0.001 vs. IL-1β (1 nM) stimulation (Bonferroni-Dunn test). The data are expressed as mean ± SD of triplicate samples from four separate representative experiments. A: *p < 0.001, (IL-1β vs. IL-1β + IL-1ra and IL-1β + AICAR), **p < 0.01 (IL-1β + AICAR vs. IL-1β + compound C). B: *p < 0.001, (IL-1β vs. IL-1β + IL-1ra and IL-1β + AICAR), **p < 0.05 (IL-1β + AICAR vs. IL-1β + compound C). C: *p < 0.001, (IL-1β vs. IL-1β + IL-1ra and IL-1β + AICAR), **p < 0.05 (IL-1β + AICAR vs. IL-1β + compound C). D: *p < 0.001, (IL-1β vs. IL-1β + IL-1ra and IL-1β + AICAR), **p < 0.05 (IL-1β + AICAR vs. IL-1β + compound C)

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