Skip to main content

Table 1 Characteristics of the studies included in the meta-analysis

From: The effects of statins on hyperandrogenism in women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials

Publication author, year Country Jadad score Treatment arm A Treatment arm B Time of therapy Sample size Outcomes Assessment method/Unit of primary outcome
Seyam 2018 [19] Egypt 5 Simvastatin(20 mg/d)
+Metformin(1.5 g/d)
Metformin(1.5 g/d) 12 months 70/65 T,DHEA, Hirsutism ELISA assay/ ng/ml
Seyam 2017 [24] Egypt 4 Simvastatin(20 mg/d) Placebo 6 months 100/100 T,DHEA, Hirsutism,Acne chemiluminescence assays/ ng/ml
Puurunen 2013 [26] Finland 5 Atorvastatin 20 mg/d Placebo 6 months 15/13 T,DHEA, And Liquid mass spectrometry/ nmol/l
Sathyapalan 2009 [22] United Kingdom 5 Atorvastatin 20 mg/d Placebo 3 months 19/18 T Immunoassay/ nmol/l
Banaszewska 2011 [27] Poland 3 Simvastatin(20 mg/d)
+Metformin(1.7 g/d)
Metformin(1.7 g/d) 6 months 36/33 T,DHEA, Hirsutism,Acne enzymatic colorimetric assays/ ng/ml
Raja 2011 [25] American 4 Atorvastatin(40 mg/d) placebo 1.5 months 9/11 T,DHEA,And Hirsutism,Acne not report/ ng/dl
Rashidi 2011 [20] Iran 5 Simvastatin(20 mg/d) placebo 2 months 32/29 T,DHEAS chemiluminescence assays/ pg/ml
Kazerooni 2010 [21] Iran 5 Simvastatin(20 mg/d)
+Metformin(1.5 g/d)
Metformin(1.5 g/d) 3 months 42/42 T,DHEA,Hirsutism Radioimmunoassay/ ng/ml
Duleba 2005 [23] Poland 2 simvastatin, 20 mg
+OCP
OCP 3 month 24/24 T,DHEA chemiluminescence assays/ ng/dl
  1. T testosterone, DHEA dehydroepiandrosterone, And androstenedione, OCP oral contraceptive pills; containing 20 μg ethinyl E2 and 150 μg desogestrel