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Table 2 Baseline characteristics and pregnancy outcomes with different levels of P and P/E2 ratio

From: Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: a retrospective cohort study

 

Progesteronea

Progesterone/estradiol (P/E2) ratioa

 

P < 0.92 ng/mL

P ≥ 0.92 ng/mL

 

P/E2 ratio < 0.3

P/E2 ratio ≥ 0.3

 

Characteristics

N = 642

N = 612

P value

N = 865

N = 389

P value

Age (years)

29.1 ± 4.0

29.4 ± 3.6

0.067

29.2 ± 3.5

29.4 ± 3.6

0.262

BMI (kg/m2)

25.6 ± 24.0

24.3 ± 21.6

0.292

24.0 ± 16.8

27.0 ± 32.4

0.036

Infertility duration (years)

4.2 ± 2.6

4.1 ± 2.6

0.485

4.1 ± 2.6

4.3 ± 2.7

0.209

AFC

23.4 ± 10.0

22.7 ± 9.3

0.200

23.7 ± 9.9

21.5 ± 8.9

<0.001

Basal FSH (IU/L)

6.5 ± 1.8

6.4 ± 2.9

0.244

6.5 ± 2.6

6.4 ± 1.9

0.634

Basal LH (IU/L)

6.8 ± 5.3

6.8 ± 4.9

0.965

7.1 ± 5.1

6.0 ± 4.9

<0.001

Basal estrogen (pg/mL)

57.2 ± 153.5

56.4 ± 141.7

0.923

61.7 ± 176.9

45.9 ± 28.8

0.083

Fasting serum glucose (mmol/L)

5.1 ± 0.7

5.1 ± 0.6

0.561

5.1 ± 0.6

5.2 ± 0.7

0.129

Follicles≥14 mma

15.2 ± 6.8

18.6 ± 7.3

<0.001

17.9 ± 7.2

14.0 ± 6.4

<0.001

Days of stimulation

11.3 ± 3.4

10.6 ± 2.8

<0.001

10.8 ± 3.2

11.3 ± 3.0

0.005

Gn dosage (IU/L)

2511.0 ± 1192.8

2373.9 ± 1037.4

0.030

2303.9 ± 1085.9

2755.8 ± 1137.2

<0.001

Serum estrogen (pg/mL) a

3378.8 ± 2035.7

5433.1 ± 3063.2

<0.001

5189.4 ± 2876.9

2584.5 ± 1380.8

<0.001

Serum Progesterone (ng/mL) a

0.6 ± 0.2

1.4 ± 0.7

<0.001

0.9 ± 0.4

1.2 ± 0.9

<0.001

Serum P/E2 ratio a

0.2 ± 0.2

0.4 ± 0.9

<0.001

0.2 ± 0.1

0.5 ± 1.1

<0.001

Endometrial thickness on ET day (cm)

1.1 ± 0.3

1.0 ± 0.2

0.002

1.0 ± 0.2

1.1 ± 0.2

0.066

Oocytes retrieved

13.1 ± 6.4

18.5 ± 7.4

<0.001

17.0 ± 7.4

12.8 ± 6.7

<0.001

2PN oocytes rate (%)

55.9% (4670/8350)

56.6% (6398/11301)

0.338

56.3%(8267/14678)

56.3%(2801/4973)

0.998

Cleavage rate of 2PN oocytes (%)

98.0% (4577/4670)

97.6% (6245/6398)

0.159

97.8%(8085/8267)

97.7%(2737/2801)

0.796

High-quality embryo rate (%)

67.4% (3147/4670)

65.3% (4181/6398)

0.025

66.7%(5518/8267)

64.6%(1810/2801)

0.040

Outcomes

      

Number of embryo transfer cycle

411

250

 

400

261

 

Cycle cancellation rate (%)

36.0% (231/642)

59.2% (362/612)

<0.001

53.8%(465/865)

32.9%(128/389)

<0.001

Rate of cancelled cycles due to inadequate endometrial thickness (%)

11.3% (26/231)

4.1% (15/362)

0.001

5.4%(25/465)

12.5%(16/128)

0.005

Rate of cancelled cycles due to OHSS prevention (%)

52.4% (121/231)

63.8% (231/362)

0.006

64.1%(298/465)

42.2%(54/128)

<0.001

Rate of cancelled cycles due to high P level (%)a

0% (0/231)

5.5% (20/362)

<0.001

1.3%(6/465)

10.9%(14/128)

<0.001

Rate of cancelled cycles due to no embryos obtained (%)

5.2% (12/231)

3.6% (13/362)

0.343

3.0%(14/465)

8.6%(11/128)

0.005

Rate of cancelled cycles due to no oocytes retrieved (%)

0.4% (1/231)

0.3% (1/362)

0.748

0.2%(1/465)

0.8%(1/128)

0.328

Rate of cancelled cycles due to other reasons (%)

30.7% (71/231)

22.7% (82/362)

0.028

26.0%(121/465)

25%(32/128)

0.815

Freeze-all cycles rate (%)

34.0% (218/642)

56.9% (348/612)

<0.001

52.0%(450/865)

29.8%(116/389)

<0.001

Implantation rate (%)

34.3% (275/802)

28.7% (139/484)

0.038

30.3% (237/782)

35.1% (177/504)

0.071

hCG+ rate (%)

61.1% (251/411)

57.2% (143/250)

0.325

57.3% (229/400)

63.2% (165/261)

0.126

Clinical pregnancy rate (%)

47.9% (197/411)

43.2% (108/250)

0.237

44.8% (179/400)

48.3% (126/261)

0.374

Ectopic pregnancy rate (%)

1.7% (7/411)

2.0% (5/250)

0.782

2.0% (8/400)

1.5% (4/261)

0.660

Early miscarriage rate (%)

4.1% (17/411)

2.8% (7/250)

0.373

4.0% (16/400)

3.1% (8/261)

0.530

Live birth rate (%)

15.6% (64/411)

14.0% (35/250)

0.583

15.8% (63/400)

13.8%(36/261)

0.491

  1. aMeasured on the day of hCG