| Progesteronea | Progesterone/estradiol (P/E2) ratioa | ||||
---|---|---|---|---|---|---|
 | P < 0.92 ng/mL | P ≥ 0.92 ng/mL |  | P/E2 ratio < 0.3 | P/E2 ratio ≥ 0.3 |  |
Characteristics | N = 642 | N = 612 | P value | N = 865 | N = 389 | P value |
Age (years) | 29.1 ± 4.0 | 29.4 ± 3.6 | 0.067 | 29.2 ± 3.5 | 29.4 ± 3.6 | 0.262 |
BMI (kg/m2) | 25.6 ± 24.0 | 24.3 ± 21.6 | 0.292 | 24.0 ± 16.8 | 27.0 ± 32.4 | 0.036 |
Infertility duration (years) | 4.2 ± 2.6 | 4.1 ± 2.6 | 0.485 | 4.1 ± 2.6 | 4.3 ± 2.7 | 0.209 |
AFC | 23.4 ± 10.0 | 22.7 ± 9.3 | 0.200 | 23.7 ± 9.9 | 21.5 ± 8.9 | <0.001 |
Basal FSH (IU/L) | 6.5 ± 1.8 | 6.4 ± 2.9 | 0.244 | 6.5 ± 2.6 | 6.4 ± 1.9 | 0.634 |
Basal LH (IU/L) | 6.8 ± 5.3 | 6.8 ± 4.9 | 0.965 | 7.1 ± 5.1 | 6.0 ± 4.9 | <0.001 |
Basal estrogen (pg/mL) | 57.2 ± 153.5 | 56.4 ± 141.7 | 0.923 | 61.7 ± 176.9 | 45.9 ± 28.8 | 0.083 |
Fasting serum glucose (mmol/L) | 5.1 ± 0.7 | 5.1 ± 0.6 | 0.561 | 5.1 ± 0.6 | 5.2 ± 0.7 | 0.129 |
Follicles≥14 mma | 15.2 ± 6.8 | 18.6 ± 7.3 | <0.001 | 17.9 ± 7.2 | 14.0 ± 6.4 | <0.001 |
Days of stimulation | 11.3 ± 3.4 | 10.6 ± 2.8 | <0.001 | 10.8 ± 3.2 | 11.3 ± 3.0 | 0.005 |
Gn dosage (IU/L) | 2511.0 ± 1192.8 | 2373.9 ± 1037.4 | 0.030 | 2303.9 ± 1085.9 | 2755.8 ± 1137.2 | <0.001 |
Serum estrogen (pg/mL) a | 3378.8 ± 2035.7 | 5433.1 ± 3063.2 | <0.001 | 5189.4 ± 2876.9 | 2584.5 ± 1380.8 | <0.001 |
Serum Progesterone (ng/mL) a | 0.6 ± 0.2 | 1.4 ± 0.7 | <0.001 | 0.9 ± 0.4 | 1.2 ± 0.9 | <0.001 |
Serum P/E2 ratio a | 0.2 ± 0.2 | 0.4 ± 0.9 | <0.001 | 0.2 ± 0.1 | 0.5 ± 1.1 | <0.001 |
Endometrial thickness on ET day (cm) | 1.1 ± 0.3 | 1.0 ± 0.2 | 0.002 | 1.0 ± 0.2 | 1.1 ± 0.2 | 0.066 |
Oocytes retrieved | 13.1 ± 6.4 | 18.5 ± 7.4 | <0.001 | 17.0 ± 7.4 | 12.8 ± 6.7 | <0.001 |
2PN oocytes rate (%) | 55.9% (4670/8350) | 56.6% (6398/11301) | 0.338 | 56.3%(8267/14678) | 56.3%(2801/4973) | 0.998 |
Cleavage rate of 2PN oocytes (%) | 98.0% (4577/4670) | 97.6% (6245/6398) | 0.159 | 97.8%(8085/8267) | 97.7%(2737/2801) | 0.796 |
High-quality embryo rate (%) | 67.4% (3147/4670) | 65.3% (4181/6398) | 0.025 | 66.7%(5518/8267) | 64.6%(1810/2801) | 0.040 |
Outcomes | Â | Â | Â | Â | Â | Â |
Number of embryo transfer cycle | 411 | 250 | Â | 400 | 261 | Â |
Cycle cancellation rate (%) | 36.0% (231/642) | 59.2% (362/612) | <0.001 | 53.8%(465/865) | 32.9%(128/389) | <0.001 |
Rate of cancelled cycles due to inadequate endometrial thickness (%) | 11.3% (26/231) | 4.1% (15/362) | 0.001 | 5.4%(25/465) | 12.5%(16/128) | 0.005 |
Rate of cancelled cycles due to OHSS prevention (%) | 52.4% (121/231) | 63.8% (231/362) | 0.006 | 64.1%(298/465) | 42.2%(54/128) | <0.001 |
Rate of cancelled cycles due to high P level (%)a | 0% (0/231) | 5.5% (20/362) | <0.001 | 1.3%(6/465) | 10.9%(14/128) | <0.001 |
Rate of cancelled cycles due to no embryos obtained (%) | 5.2% (12/231) | 3.6% (13/362) | 0.343 | 3.0%(14/465) | 8.6%(11/128) | 0.005 |
Rate of cancelled cycles due to no oocytes retrieved (%) | 0.4% (1/231) | 0.3% (1/362) | 0.748 | 0.2%(1/465) | 0.8%(1/128) | 0.328 |
Rate of cancelled cycles due to other reasons (%) | 30.7% (71/231) | 22.7% (82/362) | 0.028 | 26.0%(121/465) | 25%(32/128) | 0.815 |
Freeze-all cycles rate (%) | 34.0% (218/642) | 56.9% (348/612) | <0.001 | 52.0%(450/865) | 29.8%(116/389) | <0.001 |
Implantation rate (%) | 34.3% (275/802) | 28.7% (139/484) | 0.038 | 30.3% (237/782) | 35.1% (177/504) | 0.071 |
hCG+ rate (%) | 61.1% (251/411) | 57.2% (143/250) | 0.325 | 57.3% (229/400) | 63.2% (165/261) | 0.126 |
Clinical pregnancy rate (%) | 47.9% (197/411) | 43.2% (108/250) | 0.237 | 44.8% (179/400) | 48.3% (126/261) | 0.374 |
Ectopic pregnancy rate (%) | 1.7% (7/411) | 2.0% (5/250) | 0.782 | 2.0% (8/400) | 1.5% (4/261) | 0.660 |
Early miscarriage rate (%) | 4.1% (17/411) | 2.8% (7/250) | 0.373 | 4.0% (16/400) | 3.1% (8/261) | 0.530 |
Live birth rate (%) | 15.6% (64/411) | 14.0% (35/250) | 0.583 | 15.8% (63/400) | 13.8%(36/261) | 0.491 |