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Table 2 Frequency of lymphocytes subsets among children conceived natural conception, IVF and ICSI

From: The altered immunological status of children conceived by assisted reproductive technology

 

NC

ART

P value

% T cells (CD3+)

66.31 ± 12.80

68.79 ± 10.15

0.46

% B cells (CD19+)

12.21 ± 6.12

13.26 ± 5.85

0.57

% NK cells (CD16 + CD56+)

15.29 ± 9.39

13.25 ± 6.90

0.38

% CD8 + T cells

22.93 ± 5.80

24.33 ± 5.39

0.40

% CD4+ T cells

33.83 ± 9.03

35.95 ± 7.87

0.41

% TH1 (CD3 + CD8-IFN-γ+)

4.62(3.01, 8.44)

4.65(2.72, 6.86)

0.72

% TH17 (CD3 + CD8-IL-17+)

0.09(0.06, 0.19)

0.15(0.10, 0.25)

0.17

% Treg (CD4 + CD25hi + Foxp3+)

2.47 ± 0.74

2.32 ± 0.84

0.60

IFH-γ (pg/mL)

8.21 ± 1.75

10.85 ± 4.24

0.06

IL-4 (pg/mL)

10.41 ± 5.76

15.32 ± 7.48

0.06

IL-17A (pg/mL)

6.01 ± 2.35

6.77 ± 2.61

0.43

IL-10 (pg/mL)

4.86 ± 0.86

6.32 ± 3.14

0.20

  1. Data are expressed as average ± SD or the median (interquartile range)
  2. TH1 T helper 1, TH17 T helper 17, Treg regulatory T cells, INF-γ interferon gamma, IL-4 interleukin-4, IL-17A interleukin-17A, IL-10 interleukin-10