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Fig. 8 | Reproductive Biology and Endocrinology

Fig. 8

From: Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Fig. 8

GREM2 mediates the suppressive effects of BMP2 on the GDF8-induced increases in phosphorylated SMAD2 and SMAD3 in SVOG cells. A and B, the effects of GREM2 on the GDF8-induced increases in the phosphorylated protein levels of SMAD2 (A) and SMAD3 (B) in SVOG cells. C and D, the effects of GREM2 on the GDF8-induced increases in the phosphorylated protein levels of SMAD2 (C) and SMAD3 (D) in primary hGL cells. E, the effects of knockdown of GREM2 on the mRNA levels of GREM2 in SVOG cells. F and G, GREM2 mediates the suppressive effects of BMP2 on the GDF8-induced increases in phosphorylated SMAD2 (F) and SMAD3 (G) in SVOG cells. The results are expressed as the mean ± SEM of at least three independent experiments, and values without common letters are considered significantly different (P < 0.05)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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