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Fig. 6 | Reproductive Biology and Endocrinology

Fig. 6

From: Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Fig. 6

GREM2 suppresses the BMP2-induced increases in phosphorylated SMAD1/5/8, SMAD2 and SMAD3 and downregulation of StAR in primary and immortalized hGL cells. A and B, the effects of different concentrations of GREM2 on the BMP2-induced increases in the phosphorylated proteins of SMAD1/5/8, SMAD2 and SMAD3. C and D, the effects of GREM2 on the BMP2-induced decrease in the mRNA level of StAR in SVOG (C) and primary hGL (D) cells. The results are expressed as the mean ± SEM of at least three independent experiments, and values without common letters are considered significantly different (P < 0.05). StAR, steroidogenic acute regulatory protein

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