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Fig. 5 | Reproductive Biology and Endocrinology

Fig. 5

From: Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Fig. 5

SMAD4 mediates the BMP2-induced upregulation of GREM2 in SVOG cells. A and B, the effect of knockdown of SMAD4 on the BMP2-induced increase in the mRNA levels of SMAD4 and GREM2. C and D, the effect of knockdown of SMAD4 on the BMP2-induced increase in the protein levels of SMAD4 and GREM2. The results are expressed as the mean ± SEM of at least three independent experiments, and values without common letters are considered significantly different (P < 0.05)

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