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Fig. 4 | Reproductive Biology and Endocrinology

Fig. 4

From: Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Fig. 4

SMAD1 and SMAD5 mediate the BMP2-induced upregulation of GREM2 in SVOG cells. A and B, the effect of knockdown of SMAD1 on the BMP2-induced increase in the mRNA levels of SMAD1 and GREM2. C and D, the effect of knockdown of SMAD5 on the BMP2-induced increase in the mRNA levels of SMAD5 and GREM2. E and F, the effect of knockdown of SMAD8 on the BMP2-induced increase in the mRNA levels of SMAD8 and GREM2. The results are expressed as the mean ± SEM of at least three independent experiments, and values without common letters are considered significantly different (P < 0.05)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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