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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: Bone morphogenetic protein 2 inhibits growth differentiation factor 8-induced cell signaling via upregulation of gremlin2 expression in human granulosa-lutein cells

Fig. 2

ALK2 and ALK3 mediate the BMP2-induced upregulation of GREM2 in SVOG cells. A, B, and C, the effects of the TGF-β type I receptor inhibitors 10 μM dorsomorphin (A), 10 μM DMH-1 (B), or 10 μM SB431542 (C) on the BMP2-induced increase in the mRNA level of GREM2. D, F, and H, the effects of knockdown of ALK2 on the BMP2-induced increases in the expression of GREM2. E, G, and I, the effects of knockdown of ALK3 on the BMP2-induced increases in the expression of GREM2. The results are expressed as the mean ± SEM of at least three independent experiments, and values without common letters are considered significantly different (P < 0.05)

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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