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Fig. 3 | Reproductive Biology and Endocrinology

Fig. 3

From: microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor

Fig. 3

HB-EGF was directly targeted by miR-194. A Venn diagram demonstrates the intersection of data extracted from several bioinformatics websites. (B) Binding sites shared between miR-194 and HB-EGF. (C-D) HB-EGF protein and mRNA expression in the GCs. KGN cells were transfected for 48 h with miR-194 mimic, miR-194 inhibitor, or the miR-NC group. (E) Luciferase reporter assays. (F) miR-194 and HB-EGF mRNA expression in PCOS patient ovarian GCs. n= 3-6 for each group; *P < 0.05 vs. control group or miR-NC group

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Reproductive Biology and Endocrinology

ISSN: 1477-7827

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