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Fig. 2 | Reproductive Biology and Endocrinology

Fig. 2

From: microRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor

Fig. 2

miR-194 regulated KGN cell growth and apoptosis. (A) A CCK-8 assay assessed KGN cell viability upon treatment with miR-194 mimic or inhibitor. (B) Ki67 was utilized to determine the proliferative ability of KGN cells upon transfection with miR-194 or miR-NC inhibitors. (C-D) The AO/EB and flow cytometry were used to detect the KGN cell apoptosis. (E) p53, p21 and p16 protein level after treatment with miR-194 or miR-NC mimic. 𝑛 = 3-6 for each group. *P < 0.05 vs. miR-NC group

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